Affimed Introduces ROCK(TM) Platform for Tailored Immune Cell Engagers

Redirected Optimized Cell Killing (ROCK^TM) Platform Engages NK and T Cells to Activate Innate and Adaptive Immunity

Heidelberg, Germany, May 3, 2018 - Affimed N.V. (Nasdaq: AFMD), a clinical stage biopharmaceutical company focused on discovering and developing highly targeted cancer immunotherapies, today announced the official launch of its Redirected Optimized Cell Killing (ROCK^TM) platform. Based on the company's long-standing expertise in drug development and protein engineering, the ROCK^TM platform enables the generation of both NK cell and T cell-engaging antibodies tailored to different indications and settings.

ROCK^TM was introduced at the 14^th Annual Protein Engineering Summit in two separate presentations. A talk titled "Engineering High Affinity Tetravalent Bispecific Immune Cell Engagers to Destroy Malignant Cells with Low Target Expression" held by Dr. Michael Tesar, Research Program Head at Affimed, highlighted the core technical differentiating features including the unique modularity of the platform. Affimed has successfully generated development candidates for two ongoing preclinical NK cell engager programs, namely AFM24 and AFM26, which target EGFR for the treatment of solid tumors, or BCMA for the treatment of multiple myeloma, respectively. In his luncheon presentation titled, "Developing First-In-Class Immune Cell Engagers for the Activation of Innate and Adaptive Immunity to Fight Cancer." Dr. Martin Treder, the Company's CSO, outlined ROCK^TM's value in the context of Affimed's clinical stage tetravalent bispecific immune cell engagers and the potential for future next generation engager development.

"Our ROCK^TM platform allows us to develop high quality multi-specific antibodies with the potential to activate and redirect the body's own immune system to effectively target tumor cells," Dr. Treder commented. "Redirected optimized cell killing utilizes specific antibody formats that enable the killing of malignant cells, including cells with low target expression."

ROCK^TM is a unique modular platform suitable for the development of both NK and T cell engagers, thus employing both innate and adaptive immunity to fight cancer. ROCK^TM's modularity relies on different antibody formats, high target specificity and affinity and favorable manufacturing properties. These versatile features enable the generation of multi-specific antibodies with variable PK profiles, tissue distribution and optimal tumor and immune cell targeting.

"With our approach to arm and deploy innate and adaptive immune cells, we are focused on delivering new treatments beyond existing therapies," added Dr. Adi Hoess, Affimed's CEO. "Our ROCK^TM platform marks yet another step towards creating novel therapeutic options for patients suffering from cancer and other life-threatening diseases."

About Affimed N.V.

Affimed (Nasdaq: AFMD) engineers targeted immunotherapies, seeking to cure patients by harnessing the power of innate and adaptive immunity (NK and T cells). We are developing single and combination therapies to treat cancers and other life-threatening diseases. For more information, please visit www.affimed.com.

FORWARD-LOOKING STATEMENTS

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Forward looking statements appear in a number of places throughout this release and include statements regarding our intentions, beliefs, projections, outlook, analyses and current expectations concerning, among other things, the value of our ROCK^TM platform, our ongoing and planned preclinical development and clinical trials, our collaborations and development of our products in combination with other therapies, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals for our product candidates our intellectual property position, our collaboration activities, our ability to develop commercial functions, expectations regarding clinical trial data, our results of operations, cash needs, financial condition, liquidity, prospects, future transactions, growth and strategies, the industry in which we operate, the trends that may affect the industry or us and the risks uncertainties and other factors described under the heading "Risk Factors" in Affimed's filings with the Securities and Exchange Commission. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future.

Contact:

Anca Alexandru, Head of Communications, EU IR
Phone: +49 6221 64793341
E-Mail: [email protected], [email protected]