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Merlin Crossley

Deputy Vice-Chancellor Academic and Professor of Molecular Biology, UNSW

I have been doing molecular biology since 1985 and been in academic administration since 2004. I continue to run a large laboratory and to teach at UNSW Sydney.

My lab has a blog with posts every Friday https://wordpress.com/view/crossleylab.wordpress.com

our lab website is http://www.crossleylab.unsw.edu.au/

We work on DNA-binding proteins that facilitate epigenetic changes to turn genes on and off. We are interested in developing ways to artificially regulate the expression of particular genes. For instance, recently we have used CRISPR and other gene editing approaches to introduce beneficial mutations to boost the output of medically important genes. Such technologies may be useful in treating particular genetic diseases of the blood, like sickle cell anemia, and of metabolism, such as diabetes and obesity.

I enjoy teaching and give lectures in the area of molecular biology, genomics, epigenetics, stem cells, genetic reprogramming and genome editing.

I have written extensively on modern molecular genetics and on science teaching and education policy.

New CRISPR technology could revolutionise gene therapy, offering new hope to people with genetic diseases

Feb 02, 2021 13:12 pm UTC| Science

The day a muddled mob stormed the US Capitol building, a team of American researchers published a paper in Nature that signified a landmark in gene therapy. The head of the US National Institutes of Health, Francis...

Boyer Lectures: gene therapy is still in its infancy but the future looks promising

Oct 16, 2018 15:12 pm UTC| Insights & Views Science

This year marks the 60th anniversary of the ABCs Boyer Lectures. Delivered by Professor John Rasko, the 2018 Life Engineered lectures explore ethical and other issues around gene therapy and related technologies, and their...

When to trust (and not to trust) peer reviewed science

Jul 14, 2018 11:10 am UTC| Insights & Views Science

The article is part of our occasional long read series Zoom Out, where authors explore key ideas in science and technology in the broader context of society. The words published in a peer reviewed journal are sometimes...

Economy

China Extends Gold Buying Streak as Reserves Surge Despite Volatile Prices

Chinas central bank has continued to strengthen its gold reserves, extending its buying streak to a 15th consecutive month in January, according to the latest data released by the Peoples Bank of China (PBOC). The move...

Trump Lifts 25% Tariff on Indian Goods in Strategic U.S.–India Trade and Energy Deal

President Donald Trump has signed a landmark executive order removing the 25% penalty tariff on Indian goods, signaling a major shift in U.S.India trade relations and global geopolitical alignment. The move functions as...

Trump Signs Executive Order Threatening 25% Tariffs on Countries Trading With Iran

U.S. President Donald Trump has signed a new executive order that could impose tariffs of up to 25% on countries that continue to do business with Iran, marking a significant escalation in Washingtons pressure campaign...

U.S.-India Trade Framework Signals Major Shift in Tariffs, Energy, and Supply Chains

The United States and India have taken a significant step toward a long-anticipated bilateral trade agreement by releasing an interim trade framework aimed at lowering tariffs, reshaping energy ties, and strengthening...

Dow Hits 50,000 as U.S. Stocks Stage Strong Rebound Amid AI Volatility

U.S. stocks surged on Friday, posting their strongest session since May 2025, as investors regained confidence following a turbulent week marked by sharp losses in technology shares and uncertainty around the artificial...

Politics

Ohio Man Indicted for Alleged Threat Against Vice President JD Vance, Faces Additional Federal Charges

A federal grand jury has returned an indictment against a 33-year-old Ohio man accused of threatening to kill U.S. Vice President JD Vance during the vice presidents visit to the Ohio region in January, according to the...

New York Legalizes Medical Aid in Dying for Terminally Ill Patients

New York has officially joined a growing number of U.S. states allowing medical aid in dying after Governor Kathy Hochul signed landmark legislation into law on Friday. The new New York medical aid in dying law permits...

Trump Says “Very Good Talks” Underway on Russia-Ukraine War as Peace Efforts Continue

U.S. President Donald Trump said on Friday that very good talks are ongoing regarding Russias war in Ukraine, signaling potential movement in long-running diplomatic efforts to end the conflict. Speaking briefly to...

China Warns US Arms Sales to Taiwan Could Disrupt Trump’s Planned Visit

China has issued a strong warning to the United States, signaling that any additional arms sales to Taiwan could seriously jeopardize U.S. President Donald Trumps planned visit to China in April. According to a report...

Trump Allows Commercial Fishing in Protected New England Waters

U.S. President Donald Trump has signed a proclamation permitting commercial fishing in a previously restricted marine protected area off the coast of New England, a move that has sparked renewed debate over ocean...

Science

SpaceX Prioritizes Moon Mission Before Mars as Starship Development Accelerates

Elon Musks SpaceX is shifting its near-term space exploration strategy, choosing to prioritize a return to the Moon before pursuing missions to Mars, according to a recent Wall Street Journal report citing sources familiar...

NASA and SpaceX Target Crew-11 Undocking From ISS Amid Medical Concern

NASA has confirmed that the agency, in coordination with SpaceX, is targeting no earlier than 5 p.m. Eastern Time (2200 GMT) on Wednesday, January 14, for the undocking of the SpaceX Crew-11 mission from the International...

Neuralink Plans High-Volume Brain Implant Production and Fully Automated Surgery by 2026

Elon Musks brain-computer interface company Neuralink is preparing for a major expansion, announcing plans to begin high-volume production of its brain implant devices and transition to a fully automated surgical procedure...

Jared Isaacman Confirmed as NASA Administrator, Becomes 15th Leader of U.S. Space Agency

The U.S. Senate has officially confirmed billionaire private astronaut Jared Isaacman as the new NASA administrator, making him the 15th leader in the agencys history. The confirmation, which took place on Wednesday, marks...

Senate Sets December 8 Vote on Trump’s NASA Nominee Jared Isaacman

The U.S. Senate Commerce Committee announced it will vote on December 8 on President Donald Trumps renewed nomination of private astronaut and tech entrepreneur Jared Isaacman to lead NASA. Isaacman, known for his...

Technology

Nvidia CEO Jensen Huang Says AI Investment Boom Is Just Beginning as NVDA Shares Surge

Nvidia (NASDAQ: NVDA) CEO Jensen Huang reaffirmed his bullish stance on artificial intelligence, calling the massive capital expenditure flowing into AI infrastructure both appropriate and necessary as the industry...

Amazon Stock Rebounds After Earnings as $200B Capex Plan Sparks AI Spending Debate

Amazon.com (NASDAQ:AMZN) delivered a mixed but closely watched earnings report, beating Wall Street expectations on revenue while unveiling a massive long-term investment plan that unsettled investors. The e-commerce and...

Global PC Makers Eye Chinese Memory Chip Suppliers Amid Ongoing Supply Crunch

Major PC manufacturers including HP, Dell, Acer, and Asus are reportedly exploring the option of sourcing memory chips from Chinese semiconductor companies for the first time, as a prolonged global supply crunch continues...

OpenAI Expands Enterprise AI Strategy With Major Hiring Push Ahead of New Business Offering

OpenAI is significantly accelerating its enterprise AI strategy by hiring hundreds of new employees for its technical consulting division, according to a report by The Information, citing a person familiar with the...

SoftBank Shares Slide After Arm Earnings Miss Fuels Tech Stock Sell-Off

SoftBank Group Corp. (TYO:9984) shares tumbled sharply on Thursday, tracking a steep decline in Arm Holdings (NASDAQ:ARM) after the UK-based chip designer reported weaker-than-expected earnings for the December quarter....