Luca Peruzzotti-Jametti

Senior Research Associate and Honorary Neurology Consultant, University of Cambridge
Luca Peruzzotti-Jametti is a Senior Research Associate, Honorary Neurology Consultant, and Group Leader within the Department of Clinical Neurosciences at Cambridge University (UK), and Honorary Senior Lecturer in the Department of Metabolism, Digestion and Reproduction, Imperial College London (UK).
Luca obtained his MD from the University Vita-Salute San Raffaele of Milan, Italy (2007). He completed a residency program in Neurology at the same University (2013) and a following PhD in Clinical Neurosciences at the University of Cambridge, UK (2018). During his early graduate studies, he was a visiting scientist in major European universities, such as the University Hospital in Zürich (Switzerland), the University of Aarhus (Denmark), the Laboratory of Stem Cells and Restorative Neurology of Lund (Sweden) and the University of Innsbruck (Austria). He later progressed towards a post-doctoral position at Cambridge University (2018) and then became Group Leader within the Cambridge Center for Myelin Repair (CCMR) and Department of Clinical Neurosciences (2020).
Over the last 10+ years, Luca has made key contributions to the understanding of the pathobiology of inflammation in central nervous system (CNS) diseases. His research in regenerative neuroimmunology led to novel experimental advanced therapeutics with neural stem cells, acellular therapeutics (e.g., extracellular vesicles), and small molecules for the treatment of ischemic stroke, spinal cord injury, and progressive multiple sclerosis (MS).
Luca’s most recent work is focusing on cellular metabolism and mitochondria to find novel ways to modulate chronic inflammation and favour CNS regeneration. To this aim, he has developed unique tools to model metabolic/mitochondrial dysfunctions in vitro (using human cells and gene editing techniques) and in vivo (with animal disease models); as well as cutting edge techniques to detect metabolic changes in rodent and human cells and tissues. His multi-disciplinary approach is setting the stage for a new series of interventions that target cell metabolism in immune cells, as the next opportunity to promote the healing of the persistently inflamed CNS.
Luca’s laboratory activity is documented in >60 PubMed indexed publications - including Cell Stem Cell, New England Journal of Medicine, Nature Medicine, and Nature Chemical Biology - which have received >8,300 citations, having a Hirsch Factor of 27.