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Tamara Terzian

Assistant Professor of Dermatology, University of Colorado Anschutz Medical Campus
My laboratory is dedicated to studying the regulation of the transcription factor p53. Mutations in p53 are found in more than 50% of human cancers, making this tumor suppressor the subject of extensive basic and preclinical research. Our studies focus on 3 main topics:

1- p53 in tumorigenesis: Through the utilization of mouse models of cancer, we to unravel the role of p53 mutations in driving tumorigenesis. By understanding the underlying mechanisms that initiate and promote skin cancers like squamous cell carcinomas and melanoma, we strive to enhance cancer therapies.

2- p53 and development: Our investigation involves studying mouse models that express elevated levels of p53, which exhibit developmental abnormalities, particularly lymphatic defects. By characterizing these mice phenotypically and molecularly, we aim to identify crucial factors contributing to the pathogenesis of associated diseases. Furthermore, we are exploring the potential of certain drugs in treating the debilitating disorder of lymphedema.

3- p53 and pigmentation: Our research focuses on the activation of the p53 pathway in skin stem cells with the goal of developing treatments for pigmentary disorders such as vitiligo and giant congenital nevi. We have identified a drug that targets the p53 pathway and shows promise in promoting melanocyte proliferation and repigmentation of depigmented vitiligo skin. We are currently analyzing the mode of action of this drug in preparation for future clinical trials.

These research areas represent our ongoing efforts to deepen our understanding of the working of p53 and contribute to the advancement of cancer and lymphatic disease therapy.

Economy

India–U.S. Interim Trade Pact Cuts Auto Tariffs but Leaves Tesla Out

India and the United States have taken a significant step toward strengthening bilateral trade ties with the release of an interim trade framework that includes major tariff reductions on high-end American automobiles and...

Trump’s Inflation Claims Clash With Voters’ Cost-of-Living Reality

Donald Trump has positioned himself as the Republican Partys chief voice on the cost of living during a pivotal election year, but a Reuters review of his recent speeches shows a growing disconnect between his rhetoric and...

South Africa Eyes ECB Repo Lines as Inflation Eases and Rate Cuts Loom

South Africa is keen to make use of potential new European Central Bank (ECB) repo liquidity lines, according to central bank governor Lesetja Kganyago, as the country continues to navigate easing inflation and a gradual...

Russian Stocks End Mixed as MOEX Index Closes Flat Amid Commodity Strength

Russian stocks finished the latest trading session on a mixed note, with the MOEX Russia Index closing flat as gains in select blue-chip shares were offset by losses in others. At the close of trading in Moscow, the...

China Extends Gold Buying Streak as Reserves Surge Despite Volatile Prices

Chinas central bank has continued to strengthen its gold reserves, extending its buying streak to a 15th consecutive month in January, according to the latest data released by the Peoples Bank of China (PBOC). The move...

Politics

US Pushes Ukraine-Russia Peace Talks Before Summer Amid Escalating Attacks

The United States is pressing Ukraine and Russia to reach an agreement to end the war before the start of summer, Ukrainian President Volodymyr Zelenskiy said following two days of U.S.-brokered talks held in Abu Dhabi....

Netanyahu to Meet Trump in Washington as Iran Nuclear Talks Intensify

Israeli Prime Minister Benjamin Netanyahu is expected to meet U.S. President Donald Trump in Washington on Wednesday, with Irans nuclear program and regional security topping the agenda. The meeting comes amid renewed...

Trump Backs Nexstar–Tegna Merger Amid Shifting U.S. Media Landscape

U.S. President Donald Trump has publicly endorsed a proposed merger between Nexstar Media Group and Tegna, signaling renewed political attention on the future of local television broadcasting. In a post shared Saturday on...

Japan Election 2026: Sanae Takaichi Poised for Landslide Win Despite Record Snowfall

Japanese voters headed to the polls on Sunday in a rare winter election that could deliver Prime Minister Sanae Takaichi a commanding mandate, even as record snowfall threatened to suppress turnout in parts of the country....

Ohio Man Indicted for Alleged Threat Against Vice President JD Vance, Faces Additional Federal Charges

A federal grand jury has returned an indictment against a 33-year-old Ohio man accused of threatening to kill U.S. Vice President JD Vance during the vice presidents visit to the Ohio region in January, according to the...

Science

SpaceX Prioritizes Moon Mission Before Mars as Starship Development Accelerates

Elon Musks SpaceX is shifting its near-term space exploration strategy, choosing to prioritize a return to the Moon before pursuing missions to Mars, according to a recent Wall Street Journal report citing sources familiar...

NASA and SpaceX Target Crew-11 Undocking From ISS Amid Medical Concern

NASA has confirmed that the agency, in coordination with SpaceX, is targeting no earlier than 5 p.m. Eastern Time (2200 GMT) on Wednesday, January 14, for the undocking of the SpaceX Crew-11 mission from the International...

Neuralink Plans High-Volume Brain Implant Production and Fully Automated Surgery by 2026

Elon Musks brain-computer interface company Neuralink is preparing for a major expansion, announcing plans to begin high-volume production of its brain implant devices and transition to a fully automated surgical procedure...

Jared Isaacman Confirmed as NASA Administrator, Becomes 15th Leader of U.S. Space Agency

The U.S. Senate has officially confirmed billionaire private astronaut Jared Isaacman as the new NASA administrator, making him the 15th leader in the agencys history. The confirmation, which took place on Wednesday, marks...

Senate Sets December 8 Vote on Trump’s NASA Nominee Jared Isaacman

The U.S. Senate Commerce Committee announced it will vote on December 8 on President Donald Trumps renewed nomination of private astronaut and tech entrepreneur Jared Isaacman to lead NASA. Isaacman, known for his...

Technology

Nvidia CEO Jensen Huang Says AI Investment Boom Is Just Beginning as NVDA Shares Surge

Nvidia (NASDAQ: NVDA) CEO Jensen Huang reaffirmed his bullish stance on artificial intelligence, calling the massive capital expenditure flowing into AI infrastructure both appropriate and necessary as the industry...

Amazon Stock Rebounds After Earnings as $200B Capex Plan Sparks AI Spending Debate

Amazon.com (NASDAQ:AMZN) delivered a mixed but closely watched earnings report, beating Wall Street expectations on revenue while unveiling a massive long-term investment plan that unsettled investors. The e-commerce and...

Global PC Makers Eye Chinese Memory Chip Suppliers Amid Ongoing Supply Crunch

Major PC manufacturers including HP, Dell, Acer, and Asus are reportedly exploring the option of sourcing memory chips from Chinese semiconductor companies for the first time, as a prolonged global supply crunch continues...

OpenAI Expands Enterprise AI Strategy With Major Hiring Push Ahead of New Business Offering

OpenAI is significantly accelerating its enterprise AI strategy by hiring hundreds of new employees for its technical consulting division, according to a report by The Information, citing a person familiar with the...

SoftBank Shares Slide After Arm Earnings Miss Fuels Tech Stock Sell-Off

SoftBank Group Corp. (TYO:9984) shares tumbled sharply on Thursday, tracking a steep decline in Arm Holdings (NASDAQ:ARM) after the UK-based chip designer reported weaker-than-expected earnings for the December quarter....