Mayo Clinic trustees chose physician-scientist Matthew R. Callstrom, M.D., Ph.D., as the U.S. nonprofit’s next president and CEO, elevating an internal leader with strategy and artificial intelligence (AI) responsibilities.
Mayo said Nov. 13 that its Board of Trustees elected Callstrom to succeed current president and CEO Gianrico Farrugia, M.D. Farrugia will remain in the position while the two leaders work through the handover.
MPR News and the Minnesota Star Tribune reported that Callstrom is expected to start Jan. 1, 2027. Mayo’s announcement gives Farrugia’s final day but does not state Callstrom’s start date.
As medical director, Callstrom's portfolio covers Mayo Clinic Strategy and the AI Program; he also serves on the organization’s Board of Governors and Board of Trustees. He previously served as interim chief strategy officer and chaired the Department of Radiology in Rochester.
A body interventional radiologist, Callstrom works on image-guided cancer treatment. Mayo says his work has also involved bringing AI into medicine, including efforts to detect disease earlier and support clinicians.
The Minnesota Star Tribune reported that the appointment continues Mayo’s practice of choosing CEOs from its physician leadership ranks. Mayo’s announcement highlighted Callstrom’s experience across patient care, research, strategy and innovation.
Under Farrugia, who has led Mayo since 2019, the organization launched and developed Bold. Forward., a strategy that includes Mayo Clinic Platform, an AI-enabled care platform. Richard K. Davis, chair of the Board of Trustees, cited Callstrom’s “nearly 25 years of experience at Mayo Clinic.” Callstrom said he was “deeply honored” to lead the organization.
Farrugia is scheduled to leave the post on Dec. 31, 2026, and work with Callstrom on the transition.
