The Korea Institute of Energy Research (KIER) had developed an enzymatic process that uses agricultural waste to produce the 4-hydroxy valeric acid--an ingredient for biofuels and plastics.
The KIER's enzymatic process would hydrogenate levulinic acid, which in turn is created by subjecting non-edible agricultural waste biomass, such as rice straw and cornstalk, to an oxidation process.
In the natural world, there is no enzyme that can hydrogenate levulinic acid.
But researchers at KIER were able to modify the ternary molecule structure of an enzyme that can hydrogenate acetoacetic acid with a similar structure to levulinic acid.
That modified enzyme was then designed to be able to hydrogenate levulinic acid.
A byproduct of levulinic acid is formic acid which generates the hydrogen needed for the reaction.


FDA Lifts REMS Requirement for CAR-T Cell Cancer Therapies
U.S. Dollar Slips as Yen Finds Support on Intervention Signals and Geopolitical Risks Rise
Neuralink Expands Brain Implant Trials with 12 Global Patients
NASA Faces Major Workforce Reduction as 20% of Employees Prepare to Leave
U.S. Stocks Rally to Record Highs as AI Rebound Fuels Holiday-Shortened Session
Wall Street Ends Higher as S&P 500, Nasdaq Extend Gains Ahead of Holiday Week
Global Demand for Yuan Loans and Bonds Surges as China Pushes Currency Internationalization
Japan Revises Economic Growth Forecast as Stimulus Fuels Consumption and Investment
Cogent Biosciences Soars 120% on Breakthrough Phase 3 Results for Bezuclastinib in GIST Treatment
Oil Prices Ease in Asia as Geopolitical Risks Clash With Weak Demand Outlook
Trump Administration to Launch Autism Initiatives Targeting Acetaminophen Use and New Treatment Options
NASA Astronauts Wilmore and Williams Recover After Boeing Starliner Delay
Global Markets Rise as Tech Stocks Lead, Yen Strengthens, and Commodities Hit Record Highs
Trump and Merck KGaA Partner to Slash IVF Drug Costs and Expand Fertility Coverage
RBA Signals Possible Interest Rate Hike in 2026 as Inflation Pressures Persist 



