Immutep Announces United States Patent Grant for IMP701 Antibody

SYDNEY, Australia, March 05, 2018 -- Immutep Limited (ASX:IMM) (NASDAQ:IMMP) (“Immutep”, the “Company”) announces the grant of patent no. 9,908,936 entitled “Antibody molecules to LAG-3 and uses thereof” by the United States Patent and Trade Mark Office.

The patent was filed as a divisional application and is directed to LAG525, a humanised form of Immutep’s IMP701 antibody that was originally developed by Immutep S.A.S., now a wholly owned subsidiary of the Company.  The patent is co-owned by Novartis AG and Immutep S.A.S. and will expire on 13 March 2035. 

About IMP701 and LAG525
IMP701 is a therapeutic antibody originally developed by Immutep S.A.S. to target LAG-3.  This antagonist antibody plays a role in controlling the signalling pathways in both effector T cells and regulatory T cells (Treg). The antibody works to both activate effector T cells (by blocking inhibitory signals that would otherwise switch them off) and at the same time inhibit Treg function that normally prevent T cells from responding to antigen stimulation.  The antibody therefore removes two brakes that prevent the immune system from responding to and killing cancer cells.  In contrast, some other checkpoint antibodies in development target only the effector T cell pathway and don’t address the Treg pathway.

Rights to the development and commercialisation of IMP701 were licensed to CoStim Pharmaceuticals in 2012, which was subsequently acquired by Novartis in 2014.

LAG525, a humanised form of IMP701 is currently being evaluated in a Phase I/II clinical trial and a Phase II clinical trial, in combination with Novartis’ PD1 inhibitor PDR001 for the treatment of cancer.  Novartis has full responsibility for the continued development of the antibody program and Immutep is eligible to receive development-based milestone payments and royalties on sales following commercialisation of the antibody.

Further information on the clinical studies may be obtained at:
https://clinicaltrials.gov/ct2/show/NCT02460224 
https://clinicaltrials.gov/ct2/show/NCT03365791 

About Immutep

Immutep is listed on the Australian Stock Exchange (IMM), and on the NASDAQ (IMMP) in the U.S. 

For further information please contact:

U.S. Investors:
Jay Campbell, Vice President of Business Development and Investor Relations, Immutep Limited
+1 (917) 860-9404; [email protected]

Matthew Beck, The Trout Group LLC
+1 (646) 378-2933; [email protected]

Australian Investors/Media:
Matthew Gregorowski, Citadel-MAGNUS
+61 2 8234 0105; [email protected]

Please also refer to Immutep’s new website for further information:  www.immutep.com