Epizyme Announces Leadership Transition for Finance Organization

CAMBRIDGE, Mass., Aug. 15, 2017 -- Epizyme, Inc. (NASDAQ:EPZM), a clinical-stage biopharmaceutical company creating novel epigenetic therapies, today announced a leadership transition plan for its finance organization. Andrew E. Singer, executive vice president, finance and administration and chief financial officer of Epizyme, will be leaving the Company at the end of August to pursue other business opportunities. As part of this transition, Susan Graf, chief business officer of Epizyme, will assume responsibility for the finance organization going forward, including Epizyme’s financial reporting and analysis group.

In addition, the Company plans to appoint a senior vice president of finance who will report to Ms. Graf beginning in September, and has also secured the professional finance consulting services of Danforth Advisors during this transition.

“We are grateful to Andy for his contributions to Epizyme, which include helping to establish a number of external collaborations, strengthening the company’s financial position and serving as a key member of the management team overseeing Epizyme’s growth and strategy,” said Robert Bazemore, president and chief executive officer of Epizyme. “I want to thank Andy for his tenure and wish him well in his future endeavors. As we look ahead, I believe that our experienced management team possesses the skills and know-how to execute on the drivers for both short and long-term growth, including continuing to advance our robust tazemetostat clinical program, preparing for our first New Drug Application submission planned for 2018 and transitioning into a fully integrated, commercial-stage company.”

About Epizyme, Inc.
Epizyme, Inc. is a clinical-stage biopharmaceutical company committed to rewriting cancer treatment through novel epigenetic medicines. Epizyme is broadly developing its lead product candidate, tazemetostat, a first-in-class EZH2 inhibitor, with studies underway in both solid tumors and hematological malignancies, as a monotherapy and combination therapy and in relapsed and front-line disease. Using the Company's proprietary platform, Epizyme has pioneered the identification and development of small molecule inhibitors of chromatin modifying proteins (CMPs), such as tazemetostat. CMPs are part of the system of gene regulation, referred to as epigenetics, that controls gene expression. Genetic alterations can result in changes to the activity of CMPs, which can allow cancer cells to grow and proliferate. By focusing on the genetic drivers of cancers, Epizyme's science seeks to match targeted medicines with the specific patients that need it. For more information, visit www.epizyme.com and connect with us on Twitter at @EpizymeRx.

Cautionary Note on Forward-Looking Statements
Any statements in this press release about future expectations, plans and prospects for Epizyme, Inc. and other statements containing the words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties inherent in the initiation of future clinical studies and in the availability and timing of data from ongoing clinical studies; whether interim results from a clinical trial will be predictive of the final results of the trial; whether results from preclinical studies or earlier clinical studies will be predictive of the results of future trials; whether results from clinical studies will warrant meetings with regulatory authorities or submissions for regulatory approval; expectations for regulatory approvals to conduct trials or to market products; whether the Company's cash resources will be sufficient to fund the Company's foreseeable and unforeseeable operating expenses and capital expenditure requirements; other matters that could affect the availability or commercial potential of the Company's therapeutic candidates; and other factors discussed in the "Risk Factors" section of the Company's most recent Form 10-Q filed with the SEC and in the Company's other filings from time to time with the SEC. In addition, the forward-looking statements included in this press release represent the Company's views as of the date hereof and should not be relied upon as representing the Company's views as of any date subsequent to the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so.

Contacts:
Cheya Pope, Epizyme, Inc.
[email protected]
617-229-7561

Monique Allaire, THRUST IR
[email protected] 
(617) 895-9511