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Singapore will lift restrictions for all vaccinated travelers beginning April 1.
Travelers need not undergo a quarantine, as long as they take a pre-departure test.
Singapore Prime Minister Lee Hsien Loong hailed the development as a "major milestone" in the aviation hub's efforts to live with COVID-19 and would reconnect Singapore with the world.
Only travelers from countries on a "restricted list" will face curbs, although there are currently none on the list.
A raft of other coronavirus measures was also eased, with people in Singapore no longer required to wear masks outside, and people permitted to meet in groups of 10, up from five previously.
Singapore's approach is in contrast to rival financial hub Hong Kong, which required travelers to undergo lengthy quarantines in hotels.
Other Asia-Pacific countries that have recently announced an easing of travel restrictions include Indonesia, Malaysia, Australia, and New Zealand.
