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Andrea Kasinski

Associate Professor of Biological Sciences, Purdue University
Greater than 90% of the human genome is transcribed, yet the functional role for most transcripts is unknown. Many of these unknown transcripts fall into a class of RNAs referred to as non-coding RNAs. The general goal of the Kasinski Lab is to determine the molecular contribution of non-coding RNAs (microRNAs, lncRNA, circRNAs) in normal and disease cells, and to capitalize on this knowledge through developing RNA-based therapeutics. The current projects in the Kasinski lab are subdivided into the following:

Project 1: Ligand-mediated delivery of therapeutically relevant small RNAs
Project 2: Endogenous delivery of RNAs through secreted extracellular vesicles (ie. exosomes)
Project 3: High throughput screening for small molecule inhibitors that alter miRNA biogenesis
Project 4: Identification of miRNAs and protein-coding genes mediating drug resistance

MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

Oct 08, 2024 12:01 pm UTC|

When Victor Ambros and Gary Ruvkun discovered a new molecule they called microRNA in the 1980s, it was a fascinating diversion from what for decades had been called the central dogma of molecular biology. Recognized...

MicroRNA is the master regulator of the genome − researchers are learning how to treat disease by harnessing the way it controls genes

Nov 30, 2023 00:45 am UTC| Science

The Earth formed 4.5 billion years ago, and life less than a billion years after that. Although life as we know it is dependent on four major macromolecules DNA, RNA, proteins and lipids only one is thought to have been...

Economy

Trump Offers U.S. Insurance and Naval Escort for Tankers as Strait of Hormuz Crisis Disrupts Global Oil Trade

President Donald Trump announced Tuesday that the United States will provide political risk insurance and maritime guarantees for commercial shipping operating in the Gulf, while the U.S. Navy prepares to escort oil...

U.S. Stocks Fall as Middle East Conflict Fuels Inflation and Oil Price Concerns

U.S. stocks closed sharply lower on Tuesday as investors grew increasingly worried that the escalating Middle East conflict could persist and drive higher inflation through surging oil prices. Market volatility increased...

Oil Prices Surge to 2025 High as U.S.-Israel Conflict With Iran Threatens Global Energy Supply

Global oil prices surged sharply on Tuesday as escalating military conflict involving the United States, Israel, and Iran disrupted energy shipments across the Middle East, raising concerns about prolonged supply...

European Stocks Slide as Middle East War Fears and Rising Oil Prices Shake Markets

European shares extended their losses on Tuesday as a deepening global equity selloff rattled investors. Mounting concerns over a prolonged Middle East war and a sharp surge in oil prices fueled fears of higher inflation...

Gold Prices Surge for Fourth Day as Middle East Tensions and Strong U.S. Dollar Shape Market

Gold prices extended gains in Asian trading on Tuesday, marking a fourth consecutive session of advances as investors reacted to escalating geopolitical tensions in the Middle East. Safe-haven demand remained strong,...

Politics

Defense Contractors Move to Drop Anthropic AI After Trump Administration Ban

Major U.S. defense contractors are expected to remove Anthropics AI tools from their supply chains following a directive from the Trump administration, even though legal experts say the ban could face serious challenges in...

Santander’s $12.2B Webster Financial Deal Faces Uncertainty Amid U.S.–Spain Trade Tensions

Banco Santanders proposed $12.2 billion acquisition of U.S. regional lender Webster Financial may face delays following comments from President Donald Trump suggesting a halt in trade with Spain. According to Wells Fargo...

Middle East Air War Triggers Massive Flight Cancellations and Global Airline Disruptions

The escalating U.S. and Israeli air war against Iran has created major disruptions across the global aviation and tourism industries, forcing airlines and governments to manage the fallout as tens of thousands of travelers...

U.S. Military Strikes on Iran Complicate Xi-Trump Summit and Expose China’s Energy Risks

The recent U.S. military campaign against Iran has reshaped global geopolitics and placed Chinese President Xi Jinping in a difficult position ahead of a potential summit with U.S. President Donald Trump. Trump is expected...

Trump and Merz Meet at White House Amid Iran Strikes and Trade Tensions

U.S. President Donald Trump welcomed German Chancellor Friedrich Merz to the White House on Tuesday for high-stakes talks centered on the Iran conflict, U.S.-Israeli airstrikes, rising tariff tensions, and Europes evolving...

Science

SpaceX Pivots Toward Moon City as Musk Reframes Long-Term Space Vision

SpaceX CEO Elon Musk has revealed a significant shift in the companys near-term space exploration strategy, announcing that SpaceX is now prioritizing the development of a self-growing city on the Moon rather than focusing...

SpaceX Prioritizes Moon Mission Before Mars as Starship Development Accelerates

Elon Musks SpaceX is shifting its near-term space exploration strategy, choosing to prioritize a return to the Moon before pursuing missions to Mars, according to a recent Wall Street Journal report citing sources familiar...

NASA and SpaceX Target Crew-11 Undocking From ISS Amid Medical Concern

NASA has confirmed that the agency, in coordination with SpaceX, is targeting no earlier than 5 p.m. Eastern Time (2200 GMT) on Wednesday, January 14, for the undocking of the SpaceX Crew-11 mission from the International...

Neuralink Plans High-Volume Brain Implant Production and Fully Automated Surgery by 2026

Elon Musks brain-computer interface company Neuralink is preparing for a major expansion, announcing plans to begin high-volume production of its brain implant devices and transition to a fully automated surgical procedure...

Jared Isaacman Confirmed as NASA Administrator, Becomes 15th Leader of U.S. Space Agency

The U.S. Senate has officially confirmed billionaire private astronaut Jared Isaacman as the new NASA administrator, making him the 15th leader in the agencys history. The confirmation, which took place on Wednesday, marks...

Technology

OpenAI Explores New Code-Hosting Platform to Reduce Dependence on GitHub

OpenAI is reportedly developing a new code-hosting platform that could eventually compete with Microsofts GitHub, according to a recent report citing sources familiar with the initiative. The project is still in its early...

Facebook Outage Disrupts Thousands of Users Across the United States

Meta Platforms Facebook experienced a widespread outage on Tuesday that affected thousands of users across the United States, according to data from Downdetector.com, a website that tracks service disruptions for major...

Lockheed Martin Secures $1.9B U.S. Air Force Contract for C-130J Training and Maintenance Systems

Lockheed Martin (NYSE: LMT) has secured a $1.9 billion indefinite-delivery/indefinite-quantity (IDIQ) contract from the U.S. Department of Defense to support the C-130J Maintenance and Training System IV (JMATS IV)...

OpenAI and U.S. Defense Department Update Agreement to Clarify AI Usage Terms

OpenAI CEO Sam Altman announced that the company is working with the U.S. Department of Defense (DoD) to update their existing agreement, reinforcing clear boundaries around how OpenAIs technology, including ChatGPT, can...

OpenAI Secures $110 Billion Funding Round at $840 Billion Valuation Ahead of IPO

OpenAI has raised a record-breaking $110 billion in fresh funding, pushing the ChatGPT makers valuation to an impressive $840 billion. The massive investment round, backed by SoftBank, Nvidia, and Amazon, highlights the...