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Andrea Kasinski

Associate Professor of Biological Sciences, Purdue University
Greater than 90% of the human genome is transcribed, yet the functional role for most transcripts is unknown. Many of these unknown transcripts fall into a class of RNAs referred to as non-coding RNAs. The general goal of the Kasinski Lab is to determine the molecular contribution of non-coding RNAs (microRNAs, lncRNA, circRNAs) in normal and disease cells, and to capitalize on this knowledge through developing RNA-based therapeutics. The current projects in the Kasinski lab are subdivided into the following:

Project 1: Ligand-mediated delivery of therapeutically relevant small RNAs
Project 2: Endogenous delivery of RNAs through secreted extracellular vesicles (ie. exosomes)
Project 3: High throughput screening for small molecule inhibitors that alter miRNA biogenesis
Project 4: Identification of miRNAs and protein-coding genes mediating drug resistance

MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

Oct 08, 2024 12:01 pm UTC|

When Victor Ambros and Gary Ruvkun discovered a new molecule they called microRNA in the 1980s, it was a fascinating diversion from what for decades had been called the central dogma of molecular biology. Recognized...

MicroRNA is the master regulator of the genome − researchers are learning how to treat disease by harnessing the way it controls genes

Nov 30, 2023 00:45 am UTC| Science

The Earth formed 4.5 billion years ago, and life less than a billion years after that. Although life as we know it is dependent on four major macromolecules DNA, RNA, proteins and lipids only one is thought to have been...

Economy

Dollar Rises Amid Trade Deal Uncertainty, Yen and Franc Strengthen

The U.S. dollar edged higher Friday, rebounding from earlier losses as markets reacted to mixed signals from President Donald Trump on trade talks and monetary policy. The greenback has swung sharply this week, falling 1%...

Asian Tech Stocks Climb on Alphabet Earnings and AI Optimism

Asian stock markets mostly advanced on Friday, driven by a rally in tech shares after Alphabets strong earnings and bullish AI outlook. The U.S. tech giant beat earnings expectations and reaffirmed its commitment to...

Oil Prices Inch Up but Face Weekly Loss on OPEC+, Geopolitical Developments

Oil prices edged higher early Friday but remained on track for a weekly decline amid rising supply prospects and mixed signals on global demand. Brent crude futures rose 5 cents to $66.60 a barrel, while U.S. West Texas...

AI Stock Rally Lifts Futures as Alphabet Leads Tech Surge

U.S. stock index futures rose Thursday evening, driven by strong earnings from Alphabet Inc. and renewed investor enthusiasm for artificial intelligence (AI) and tech stocks. Alphabet (NASDAQ:GOOGL) jumped nearly 5% in...

BoJ Rate Hike Odds Rise as Tokyo Inflation Surges Beyond Expectations

Tokyos consumer inflation surged in April, reinforcing expectations that the Bank of Japan (BoJ) may raise interest rates sooner than anticipated. According to ING analysts, a sharper-than-expected rise in Tokyos core...

Politics

Japan Unveils Emergency Economic Plan to Offset U.S. Tariff Impact

Japanese Prime Minister Shigeru Ishiba announced on Friday a new emergency economic package aimed at cushioning households and industries from the effects of recent U.S. import tariffs. The relief plan, outlined in a...

Moon Jae-in Criticizes Prosecutors Amid Bribery Indictment

Former South Korean President Moon Jae-in accused the countrys prosecutors of political bias and abuse of power following his recent indictment on bribery charges. Speaking on Friday during a meeting with National Assembly...

Pentagon Removes Advisory Members Amid Strategic Shift

U.S. Defense Secretary Pete Hegseth has dismissed several members of Department of Defense advisory committees following a comprehensive 45-day internal review, according to a statement released Thursday by Pentagon...

Russia Uses North Korean Missile in Kyiv Strike, Killing 12

Ukrainian President Volodymyr Zelenskiy confirmed that a North Korean ballistic missile was used by Russia in a deadly airstrike on Kyiv, killing 12 civilians. The missile, identified as a KN-23 (KN-23A), hit a residential...

Trump Urges Putin to Halt Kyiv Missile Strikes Amid Peace Talks

At least 12 people were killed and 90 wounded after Russia launched its largest missile and drone attack on Kyiv this year, devastating buildings and sparking fires across the Ukrainian capital. The assault drew a rare...

Science

Kennedy Sets September Deadline to Uncover Autism Causes Amid Controversy

U.S. Health and Human Services Secretary Robert F. Kennedy Jr. announced a bold plan to identify the cause of autism by September 2025. Speaking at a cabinet meeting with President Donald Trump, Kennedy declared a global...

AstraZeneca’s Imfinzi Gets US Approval for Bladder Cancer Treatment

AstraZenecas drug Imfinzi (NASDAQ: AZN) has received U.S. approval to treat adult patients with muscle-invasive bladder cancer, a significant advancement in cancer therapy. The approval allows Imfinzi to be used in...

Sanofi’s New Hemophilia Drug Qfitlia Gains FDA Approval with Breakthrough Bimonthly Dosing

The U.S. Food and Drug Administration (FDA) has approved Qfitlia, a groundbreaking hemophilia treatment by French pharmaceutical giant Sanofi (NASDAQ: SNY). Designed for patients aged 12 and older with hemophilia A or B,...

FDA Vaccine Chief Peter Marks Resigns Amid Controversy Over Transparency

Peter Marks, the U.S. Food and Drug Administrations (FDA) top vaccine official, has resigned after reportedly being forced out by the Department of Health and Human Services (HHS), according to The Wall Street Journal....

Museums have tons of data, and AI could make it more accessible − but standardizing and organizing it across fields won’t be easy

Ice cores in freezers, dinosaurs on display, fish in jars, birds in boxes, human remains and ancient artifacts from long gone civilizations that few people ever see museum collections are filled with all this and more....

Technology

Apple Plans to Shift All U.S. iPhone Production to India Amid China Trade Tensions

Apple Inc. (NASDAQ: AAPL) is reportedly planning to shift all iPhone assembly for the U.S. market to India as early as next year, in a strategic move to reduce reliance on China amid escalating U.S.-China trade tensions,...

Chinese AI Startup Behind Manus Raises $75M, Targets Global Expansion

Chinese AI startup Butterfly Effect, the creator of Manus AI, has raised $75 million in a funding round led by U.S.-based venture capital firm Benchmark, according to a Bloomberg report citing sources familiar with the...

Intel Sees Surge in Older Chip Demand Amid U.S.-China Trade War Fears

Intel (NASDAQ: INTC) is experiencing a rise in demand for its older-generation PC and server chips as the U.S.-China trade war intensifies, executives revealed after the companys latest earnings release. Economic...

Baidu Launches Advanced Ernie AI Models to Compete in China’s Growing AI Race

Baidu (NASDAQ:BIDU) has launched upgraded versions of its Ernie artificial intelligence models, intensifying its push in Chinas fast-evolving AI landscape. At a developer conference held in Wuhan, CEO Robin Li introduced...

South Korea Flags DeepSeek for Unauthorized Data Transfers to China and U.S.

South Koreas Personal Information Protection Commission (PIPC) has accused Chinese AI startup DeepSeek of transferring personal user data and prompt content without consent during its app launch in January 2025. The PIPC...