Wall Street Ends Mixed as Apple, Eli Lilly Rise Amid Trade and Rate Concerns

Wall Street closed mixed on Thursday as investor sentiment improved slightly amid progress in U.S.-Japan trade talks, though caution prevailed ahead of the Good Friday holiday. The S&P 500 inched up 0.13% to 5,282.70, while the Nasdaq dipped 0.13% to 16,286.45. The Dow Jones slid 1.33% to 39,142.23, dragged down by UnitedHealth’s 22% plunge after the insurer cut its profit forecast due to surging medical costs.

Eli Lilly shares jumped 14% after reporting its experimental pill matched the performance of Ozempic in reducing blood sugar and weight. Apple rose 1.4%, rebounding from recent losses. However, broader sentiment remained cautious as traders eyed President Donald Trump's tariff strategy and comments on potential trade agreements with China and Japan. Trump criticized Federal Reserve Chair Jerome Powell and called for rate cuts, raising concerns over central bank independence.

Market volumes were lighter than usual, with 14.6 billion shares traded versus a 20-day average of 19.2 billion. Energy and consumer staples led gains among S&P 500 sectors, up 2.3% and 2.2%, respectively.

Despite Thursday’s slight recovery, major indexes logged weekly losses: the S&P 500 fell 1.5%, the Nasdaq 2.6%, and the Dow 2.7%. Since April 2—when Trump announced global tariffs—the S&P 500 remains down roughly 7%.

In extended hours, Netflix gained 2.5% after beating earnings forecasts and issuing a bullish outlook. Meanwhile, Alphabet shares dropped 1.4% following a legal ruling that Google illegally dominated ad tech markets.

Jobless claims data showed stable labor conditions, but businesses remain cautious due to tariff uncertainties. As recession risks rise and investors demand clear trade outcomes, market volatility is expected to persist in the weeks ahead.