Research Fellow in Microbial Evolution, Manchester University
I am a Wellcome Trust Research Fellow in Microbial Evolution Research Manchster (MERman) and the Manchester Fungal Infection Group (MFIG, http://www.inflammation-repair.manchester.ac.uk/mfig).
My main research interests are: One Health and Fungal infections, Antimicrobial Resistance (AMR), Climate change and Genetic tools in non-model organisms (Fungal pathogens)
I started my Research career at the University of Manchester obtaining my PhD. This project was focused on transcriptional regulation during Aspergillus fumigatus infection of the mammalian lung through high-throughput screening of mutants. As an example, we screened the library for azole sensitivity and resistance where my passion for AMR came from.
During my PhD project we have developed CRISPR methodologies for genome editing of A. fumigatus. The focus was on CRISPR-mediated protein tagging and point mutations to avoid using dominant selection markers during transformation. This methodology is widely adopted now in several research laboratories and is still driving much of my research.
I am currently working on a project linking climate change to antifungal resistance, working on dual-use fungicides and novel antifungals. I work on evolution in soil through various techniques combining environmental microbiology, molecular fungal biology and infection biology.