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Claire Booth

Professor of Gene Therapy and Paediatric Immunology, UCL
Claire is Professor of paediatric immunology and gene therapy at UCL Great Ormond Street Hospital Institute of Child Health in London and leads the clinical stem cell gene therapy programme at Great Ormond Street Hospital. She is a clinical academic leading an expanding number of gene therapy clinical trials for patients with immune deficiencies, haematological and metabolic disorders. Her research is focused on developing novel therapies for immune system disorders using innovative gene modification techniques. She has extensive experience of translating, leading, and delivering first in human clinical trials and the commercialisation pathway. As an attending physician she oversees the clinical management of patients with immune deficiencies, including hematopoietic stem cell transplantation and maintains a strong interest in HLH disorders.
Claire is an elected board member of the European and American Societies of Gene and Cell Therapy, serves on the editorial board of several journals and grant review committees and holds an honorary position at Boston Children’s Hospital and Harvard Medical School.
She is also the co-founder of the AGORA initiative (Access to Gene therapies fOr Rare disease) which brings together European academic developers and patient organisations, aiming to facilitate access to effective gene therapies for treatment of patients with ultra-rare diseases.

No commercial incentive to develop gene therapy – hospitals will try to fill the gap

Jun 13, 2024 06:12 am UTC| Insights & Views Business

Individually, rare diseases are rare, but there are so many rare diseases that over 400 million people are affected worldwide. Together, rare diseases arent so rare. Only 5% of rare diseases have an approved treatment...

Economy

Trump Imposes New US Tariffs on Drone Imports Over National Security Concerns

U.S. President Donald Trump announced new tariffs on imported drones and drone components on Thursday, citing national security concerns and the countrys heavy reliance on foreign suppliers. Under a proclamation signed by...

Canada-US Trade Talks Gain Momentum Ahead of Aug. 19 Tariff Deadline

Canada-US trade negotiations are making positive progress as both countries push to reach an agreement before new U.S. tariffs on Canadian imports are scheduled to take effect on Aug. 19, according to a Canadian government...

Oil Prices Fall as U.S. Crude Inventories Surge and Hormuz Tensions Persist

Oil prices declined Thursday as unexpectedly large U.S. crude inventories, weaker global demand forecasts and continued tensions surrounding the Strait of Hormuz weighed on the market. Brent crude futures for October...

Gold Prices Retreat From Two-Month High as Softer Inflation Eases Fed Rate Hike Bets

Gold prices fell Thursday as investors took profits after bullion recently climbed to a fresh two-month high. Despite the pullback, softer U.S. inflation data continued to support the precious metal by reducing...

Wall Street Hits Record High as Softer Inflation Data Eases Fed Rate Hike Fears

Wall Street closed at a record high Thursday as softer U.S. producer inflation data reduced expectations for a Federal Reserve rate hike, boosting technology stocks and pushing Treasury yields lower. The SP 500 gained 0.7%...

Politics

Israel Warned US of Alleged Iran Plot to Assassinate Trump

Israel repeatedly warned the United States over the past year that Iran may have been planning to assassinate President Donald Trump, although U.S. intelligence agencies were unable to independently verify several of the...

Putin Visits Disputed Kuril Island, Sparking Strong Protest From Japan

Russian President Vladimir Putin visited the disputed island of Iturup on Thursday, triggering a sharp diplomatic protest from Japan amid longstanding tensions over the Kuril Islands. Known as Iturup in Russia and Etorofu...

Israeli Troops Enter Qusra Homes as West Bank Settler Siege Continues

Israeli troops took positions inside Palestinian homes in Qusra in the occupied West Bank on Thursday as families remained caught in a days-long siege involving Israeli settlers, according to the village mayor and...

North Korea Slams US-South Korea Drills, Vows Stronger Nuclear Deterrence

North Korea on Friday condemned upcoming U.S.-South Korea military drills, describing this years exercises as more provocative than those held in 2025 and warning of stronger measures to counter what it sees as growing...

Trump Orders U.S. Navy to Return to Steam Catapults for Aircraft Carriers

U.S. President Donald Trump has ordered the U.S. Navy to replace its electromagnetic aircraft launch systems with traditional steam catapults, marking a major shift in the technology used aboard the Navys newest aircraft...

Science

Blue Origin New Glenn Explosion Could Delay Launch Operations Until 2028

Blue Origin is facing a significant setback after a dramatic explosion involving its New Glenn rocket severely damaged a launch pad at Cape Canaveral, Florida. According to NASA Administrator Jared Isaacman, repairs to the...

Blue Origin New Glenn Rocket Explodes During Launch Pad Test, Delaying Space Ambitions

Blue Origin suffered a major setback after its uncrewed New Glenn rocket exploded during a launch pad test in Florida on Thursday, raising new challenges for Jeff Bezos space company as it competes with Elon Musks SpaceX...

SpaceX Delays Starship V3 Launch Ahead of Potential Record IPO

SpaceX on Thursday postponed the highly anticipated launch of its 12th Starship rocket test from Texas after technical issues interrupted the final countdown. The company now plans to attempt the Starship V3 launch again...

Trump Administration Releases New UFO Files and Apollo Mission Records

The U.S. Defense Department has released dozens of previously classified UFO-related files following an order from President Donald Trump, sparking renewed debate over unidentified anomalous phenomena (UAP) and government...

China vs. NASA: The New Moon Race and What's at Stake by 2030

The space race is back and this time, its a direct competition between the United States and China for dominance on the lunar surface. NASAs Artemis II mission recently made history when four astronauts flew farther into...

Technology

Anthropic Eyes $6B Decart AI Acquisition Ahead of Mega IPO

Anthropic is reportedly in talks to acquire Nvidia-backed AI startup Decart AI as the Claude developer looks to expand its computing capabilities and address growing demand ahead of a potential public listing. Bloomberg...

Google Pushes Gemini AI Overhaul as Sergey Brin Targets Model Supremacy

Google co-founder Sergey Brin has stepped up efforts to accelerate development of the companys Gemini AI models as Alphabet battles OpenAI and Anthropic for leadership in artificial intelligence. Brin has reportedly urged...

Lenovo Revenue Surges 43% as AI Demand Drives Record First-Quarter Growth

Lenovo Group reported record first-quarter revenue as booming demand for artificial intelligence infrastructure and AI-enabled devices fueled strong growth across its major businesses, pushing its Hong Kong-listed shares...

Cisco Forecasts Strong Fiscal 2027 Growth as AI Networking Demand Surges

Cisco Systems has issued a stronger-than-expected fiscal 2027 outlook, fueled by rising demand for networking equipment and artificial intelligence infrastructure from hyperscale customers. The networking technology giant...

Super Micro Stock Jumps 19% as AI Server Demand Drives Strong 2027 Outlook

Super Micro Computer (NASDAQ: SMCI) shares surged about 19% on Wednesday after the AI server maker issued fiscal 2027 guidance that significantly exceeded Wall Street expectations, easing concerns following its softer...